Lasalocid
|
Divalent ionophore
|
75–125
|
Disruption of ion balance across biological membranes and therefore membrane potential, stimulation of mitochondrial ATPase activity
|
Avatec—5
|
1977
|
Maduramicin
|
Monovalent glycosidic ionophore
|
5–6
|
Disruption of ion balance across biological membranes by formation of complexes with lipid soluble cations
|
Cygro—5
|
1989
|
Monensin
|
Monovalent ionophore
|
100–110
|
Combines with sodium and potassium cations to form lipid-soluble complexes causing NA+ influx and disruption of membrane permeability to result in osmotic cell lysis
|
Elancoban—1
|
1971
|
Coxidin—1
|
Monimax (with nicarbazin)—0
|
Narasin
|
Monovalent ionophore
|
60–80
|
Forms dynamically reversible lipid soluble complexes with cations which alters transmembrane ion gradients and electrical potentials. Commonly used in combination with nicarbazin
|
Monteban—0
|
1986
|
Maxiban (with nicarbazin)—0
|
Salinomycin
|
Monovalent ionophore
|
44–66
|
Complexly binding monovalent cations, particularly potassium ions, promoting efflux into the cell mitochondria and cytoplasm
|
Sacox—0
|
1983
|
Semduramicin
|
Monovalent glycosidic ionophore
|
25
|
Disruption of ion balance across biological membranes by formation of complexes with lipid soluble cations
|
Aviax—5
|
1995
|
Decoquinate
|
Synthetic
|
30
|
Inhibition of the parasite mitochondrial electron transport and therefore respiration
|
Deccox—3
|
1967
|
Diclazuril
|
Synthetic
|
1
|
Interference in nucleic acid and parasite wall synthesis producing thickened incomplete oocyst walls, disruption of mitochondrial transmembrane potential
|
Coxiril—0
|
1990
|
Clinacox—5
|
Halofuginone
|
Synthetic
|
3
|
Unknown
|
Stenorol—5
|
1975
|
Nicarbazin
|
Synthetic
|
125
|
Acts as a calcium ionophore by increasing lipoprotein lipase activity, interferes with cholesterol metabolism and the formation of vitelline membrane. Commonly used in combination with narasin
|
Maxiban (with narasin)—0
|
1955
|
Monimax (with monensin)—0
|
Robenidine
|
Synthetic
|
33
|
Respiratory chain phosphorylation, ATPase and oxidative phosphorylation inhibition and energy metabolism interference, prevention of merozoite development
|
Robenz—5
|
1972
|