Fig. 4

Aiming to produce reproductively confined Atlantic salmon, Wargelius et al. (2016) knocked out dnd, which encodes a factor required for survival of germ cells. The induced dnd mutations produced fish lacking germ cells. Kleppe et al. (2017) showed that germ cell-free salmon remained immature and did not undergo puberty. Top left: Wild-type female; inset picture shows developed ovaries. Top right: Dnd-knockout female showing no ovarian development. Bottom left: Wild-type male with developed testes. Bottom right: Dnd-knockout male with undeveloped testes