Fig. 2

Diagram of CD163 exon 7 coding region and repair outcomes from selected publications. Corresponding encoded coding region of the carboxyl-terminal end of exon 6 (yellow highlight), the entire coding region of exon 7 (gray highlight) and the amino-terminal end of exon 8 (blue highlight) is shown for wild-type CD163 polypeptide. Wild-type CD163 protein sequence is compared to selected predicted translation products encoded by published edited CD163 genes. For Whitworth et al.(Whitworth et al. 2015) and Yang et al. (Yang et al. 2018), amino acids in red represent extension of the CD163 predicted products as a result of translational frame-shifts encoded by the CD163 messenger RNA. For Burkard et al. (Burkard et al. 2017), a deletion of exon 7 and fusion of exon 6 to exon 8 encodes a shortened CD163 polypeptide and the generation of a glycine codon at this junction (G). For Guo et al. (Guo et al. 2019), the small deletion within exon 7, encodes a CD163 polypeptide shortened by 41 amino acids